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Overview :
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| Filtration Probe |
ESIP |
Sterile Sampling |
| Bioreactor |
Fermenter |
Laboratory |
| Process Monitoring |
Production |
HPLC |
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Filtration Sampling Probe by TRACE
the solution for sterile substrate sampling
The filtration probe ESIP is designed to withdraw sterile, cell-free filtrate from fermenters and bioreactors.
The tubular micro-filtration poly-propylene membrane, supported by a stainless steel probe, is positioned inside the reaction vessel.
The filtration probe ESIP is sterilized together with the fermenter/bioreactor. Configured in either 12 mm, 19 mm or 25 mm diameters, the sampling module is installed in the vessel's standard METTLER-TOLEDO (IngoldTM) ports.
Flow rates of up to 1,5 ml/min are feasible; optimising filtration performance and minimizing sample consumption. Sterile cell-free filtrate can be withdrawn intermittently or continuously, manually or automatically from the head of the sampling device, which is outside the bioreactors or fermenters. A low-capacity peristaltic pump is typically used for withdrawal.
Features:
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sterile Filtration; no solids > 0.2 m |
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low dead volume |
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increased safety by using a solid membrane |
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succesfully operated in various processes |
Benefits:
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no sample conditioning like centrifugation necessary |
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samples are representative |
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easy handling |
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more safety against infections by bugs |
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safety by using a solid membrane |
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to be used with on-line analyzers ProcessTRACE, MultiTRACE and ProcessMonitor |
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sampling system for on-line HPLC and other analyzers |
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can be used in small bioreactors of approx. 300 ml volume by shortening the length of the membrane from 120 mm to 40 mm. (See our news from 27/12/2025) |
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Technical Specifications:
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| Sampling technique | in line filtration, sterile |
| Membrane module | tubular PP-membrane, pre-fabricated |
| Adapter [mm] | 19, 25 |
| Installation | 19, 25 mm IngoldTM standard port |
| Extension [mm] | each 100 |
| Flow rate [ml/min] | 1.5 |
| Volume per measurement | 3 ml in continuous processes |
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