Publikationen

Implementation of a new method for online glucose control in a 10 L CHO bioprocess

More than 75% of recombinant therapeutic proteins are produced using mammalian cell culture process. Weiterlesen

Veröffentlichung: EuroPACT 2017 in Potsdam

Online Controlling of Glucose in Cultivations and Fermentations - demonstrated in Acetone Production with a recombinant E.coli

Glucose is used as substrate for many microbial and eukaryotic cells. In cell cultivations and microbial fermentations, the glucose concentrations has to be monitored. Weiterlesen

Veröffentlichung: ProcessNet Jahrestagung und 32. Dechema Jahrestagung der Biotechnologen 2016 in Aachen

Optimized fedbatch fermentation by use of online glucose measurement

Advanced process control with multivariate feeding strategies. Weiterlesen

Veröffentlichung: ProcessNet Jahrestagung und 32. Dechema Jahrestagung der Biotechnologen 2016 in Aachen

Automatisierung von Weingärungen mittels online Enzymanalyzer zur Bestimmung von Glucose und Fructose

Die Optimierung der alkoholischen Gärungen in der Weinbereitung stellt keine einfache Aufgabe dar. Im Vergleich zu industriellen Fermentationen, bei denen vor allem eine maximale Ausbeute von Stoffwechselmetaboliten im Vordergrund steht, wird bei der Weinbereitung vor allem auf höchste Qualität des Endprodukts gelegt. Weiterlesen

Veröffentlichung: ProcessNet Jahrestagung und 32. Dechema Jahrestagung der Biotechnologen 2016 in Aachen

Process optimization by the use of substrate feeding strategies with an integrated online glucose measuring tool

In the biotechnological production of market-relevant industrial chemicals, fed- batch fermentation is a common method to obtain high cell densities and thus higher space-time yield. On this occasion, substrate supply is an important parameter for process regulation. Glucose is the most important substrate for microorganisms and animal cell lines in bioprocesses. Integrated glucose monitoring tool TRACE C2 Control is used to keep the substrate concentration on a defined level. Weiterlesen

Veröffentlichung: BioProcessing Days 2016 in Recklinghausen

Online-Controlling of Glucose in Cultivations and Fermentations

Glucose is used as substrate for many microbial and eukaryotic cells. In cell cultivations and microbial fermentations the glucose concentration has to be monitored. Furthermore it is beneficial to control the glucose concentration on a certain level to reduce the formation of by-products. In most of the processes low glucose concentrations in the medium will be preferred. Weiterlesen

Veröffentlichung: EuroPACT 2014 in Barcelona, Spanien

Online Glukoseregelung zur Kultivierung von tierischen und humanen Zelllinien

Glukose ist das Substrat für sehr viele tierische und humane Zelllinien. In allen diesen Zellkultivierungen muss die Glukosekonzentration überwacht werden. Darüber hinaus ist es in vielen Prozessen vorteilhaft, die Glukosekonzentration auf einem bestimmten Wert zu regeln, um die Bildung von Nebenprodukten zu reduzieren. Weiterlesen

Veröffentlichung: Kooperationsforum "Technologien für zellbasierte Therapien" 2014 in Erlangen

Online-Ethanol and Online-Methanol Measurements in Fermentation Processes

Ethanol and methanol are products of various microorganisms. Depending on the process they can be main product, by-product, or can be used as inducer. In a lot of processes it is important to monitor the amount of ethanol or methanol in order to know the end point of the fermentation or to avoid a toxic concentration inside the fermentation broth. Weiterlesen

Veröffentlichung: Frühjahrstagung der Biotechnologen 2013 in Frankfurt

On-line glucose measurement in disposable bioreactors

The use of disposables in biopharmaceutical processes has increased significantly during the last few years, both for improved performance and for the economic advantages they offer. However, there is a need for additional sensors that will enable the disposable process to be integrated in compliance with the latest Process Analytical Technologies. Weiterlesen

Veröffentlichung: Biopharmaceuticals 2010 in Benediktbeuern

Single-use bioreactor for high density bacterial fermentation

Single-use bioreactors have many advantages for R&D fermentation process development. Rapid system implementation, increased flexibility in size and turn-around, reduced infrastructure, reduced cross contamination risk and minimized maintenance requirement are main drivers. Weiterlesen

Veröffentlichung: RPP6 Conference University of BOKU 2011 in Wien, Österreich

Control of critical process parameters using in-situ analytics

How bioprocess engineers can improve control of their bioreactors using dedicated, real-time, on-line sensors. Weiterlesen

Veröffentlichung: Bioprocess International 2017 by Dan Kopec, Sartorius Stedim Biotech